The mechanism of action of multidrug-resistance reversing activity of torilin was
studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that
MDR reversing effects of torilin would directly be associated with the increase of
the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore,
torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin
might function by inhibiting drug transport mediated by P-glycoprotein
Torilin -
Torilis japonica
- Umbelliferae - multidrug-resistance (MDR) - drug accumulation and efflux - membrane
ATPase - drug transport